It is rarely observed in adults with only eleven cases reported to date. Autoimmune enteropathy aw toh i myoon en tuh rop uh thee is a rare condition that causes children to have a lot of diarrhea often to the point of needing intravenous iv fluidsit can also affect a childs ability to absorb food and vitamins.
Autoimmune enteropathy is a rare disorder in which the immune system causes damage to the lining of the intestines.
Autoimmune enteropathy. A very rare condition that occurs when the bodys own immune system attacks the intestinal wall and affect the way it absorbs food. Autoimmune enteropathy occurs when the immune system attacks the intestines which leads to frequent diarrhea and other nutritional problems in children. Autoimmune enteropathy aie is a rare disease characterized by intractable diarrhea villous atrophy of the small intestine the presence of autoantibodies and usually the need for immunosuppressive treatment 16patients do not respond to dietary modification including a gluten free diet and some will require total parenteral nutrition 16.
Symptoms of autoimmune enteropathy aie can be very debilitating including severe diarrhea with malabsorption and weight loss symptoms that mimic refractory celiac disease but aie does not respond to any dietary modification such as a gluten free diet. More detailed information about the symptoms causes and treatments of autoimmune enteropathy is available below. Autoimmune enteropathy is a rare disorder characterized by severe and protracted watery diarrhea early in life not responsive to dietary restriction and defined by the presence of circulating antibodies to enterocytes along with a duodenal mucosal biopsy that shows total villous atrophy crypt hyperplasia and a dense lymphoplasmacytic infiltrate in lamina propria120121.
A disorder of the small intestine featuring severe atrophy of the absorptive villi and circulating antibodies against the cells that form the lining of the intestine enterocytes. Some adult autoimmune enteropathy cases have been discovered in the workup of patients thought to have celiac disease but who do not respond to removal of gluten from the diet. Autoimmune enteropathy aie is a rare disorder of the immune system condition that affects infants young children and rarely adults causing severe diarrhea vomiting and other morbidities of the digestive tractaie causes malabsorption of food vitamins and minerals often necessitating replacement fluids and total parenteral nutrition.
For pediatric autoimmune enteropathy with associated polyendocrinopathy see ipex syndrome. An autoimmune disorder refers to a medical condition in which the immune system mistakenly attacks the bodys own organs and tissues thinking they are a foreign invader. Autoimmune enteropathy occurs when the bodys own immune system attacks itself and irritates or inflames the lining of the intestine.
The condition does not respond to a gluten free diet but there is a good response if this is combined with treatment directed against the. Autoimmune enteropathy is a heterogeneous disease and should be considered in. Autoimmune enteropathy is a rare cause of intractable diarrhea associated with circulating gut autoantibodies and a predisposition to autoimmunity.